The treatment of recurrent tumors should be considered according to the recurrence site, tumor size, intracranial pressure, patient’s general status and previous treatment. If the patient is in good general condition and the local recurrent tumor with obvious occupancy effect, surgical treatment is recommended. For patients who are not suitable for reoperation, radiation therapy and/or chemotherapy may be recommended; if those who have received previous radiation therapy are not suitable for reirradiation, chemotherapy will be recommended. For patients with high-grade glioma who have not received TMZ chemotherapy in their first treatment, the standard TMZ chemotherapy regimen is still recommended after recurrence. TMZ dose-intensity regimen, TMZ in combination with platinum drugs, and irinotecan in combination with bevacizumab may be recommended for the treatment of recurrent glioblastoma. Patients with recurrent glioblastoma may be recommended for various investigational therapies including molecularly targeted therapies, gene therapy, and immunotherapy.