There is a lack of medication for the core symptoms of childhood autism, and medication is an adjunctive symptomatic treatment measure. 1. Basic principles (1) Weighing developmental principles: rehabilitation training is the main focus for children aged 0-6 years, and the use of drugs is not recommended. If behavioral problems are prominent and other interventions are ineffective, drugs can be used with caution under the premise of strictly grasping the indications or target symptoms. children over 6 years old can choose drugs appropriately according to the target symptoms, or the extent to which comorbidities affect the child’s life or rehabilitation training. (2) The principle of balancing the side effects of medication with the efficacy: medication is only a symptomatic, temporary and supplementary measure for children with autism, so the decision of whether to choose medication should be made carefully based on full consideration of the side effects. (3) Principle of informed consent: The possible effects and risks must be explained to the guardians of children with autism before using medication, and medication should be used with fully informed and signed informed consent. (4) Principle of single, symptomatic medication: As an adjunct, medication should be considered only when certain symptoms are prominent (e.g., severe stereotyped repetitive, aggressive, self-injurious, and destructive behaviors, severe emotional problems, severe sleep problems, and extreme hyperactivity). Medications should be selected based on their class, indications, safety and efficacy, and should be used singly whenever possible. (5) Principle of gradual dose increase: The starting dose should be decided according to the individual differences in age, weight and health status of children with autism, and the dose should be increased day by day or week by week depending on the clinical effects and side effects until the target symptoms are controlled. The dose of the drug should not exceed the recommended dose in the drug instruction. 2, the main side effects of various drugs (1) antipsychotics mainly include tremors, hand tremors, muscle ankylosis and other extrapyramidal side effects, as well as weight gain, prolactin and other neuroendocrine side effects, and some children have a sedative effect. Gastrointestinal reactions such as dry mouth, nausea and vomiting are occasionally seen. (2) Antidepressants include gastrointestinal discomfort, anorexia, nausea, diarrhea, headache, anxiety, nervousness, insomnia, lethargy, sweating, trembling, dizziness or light-headedness. Use with caution or forbidden for those with poor liver or kidney function. (3) hyperactivity, attention deficit treatment drugs including epigastric discomfort, nausea, weakness, panic and elevated blood pressure, etc. 3. Chinese medicine treatment In recent years, there have been case reports of using acupuncture, tonics and other Chinese medicine methods to treat autism in children, but the treatment effect has yet to be verified.