Treatment of neuroblastoma is unsatisfactory. Currently, a combination of chemotherapy-surgery-chemotherapy approach is generally used. The impact of surgery on its prognosis is also controversial. We have adopted the vascular skeletonization method, which has greatly improved the complete surgical resection rate of stage 3 and 4 neuroblastoma and significantly increased the postoperative survival rate. We calculated an overall 5-year survival rate of 72.72%, which is much higher than that reported in the domestic and international literature, and the complication rate is very low. Therefore, we conclude that the thoroughness of surgical resection is directly proportional to the long-term survival of children with neuroblastoma. The more thorough the surgery, the greater the surgical risk and the more surgical complications. We believe that physicians should put the safety of the child’s surgery first and thoroughness second. It is important not to risk the child’s life for the sake of surgical thoroughness. Complications are also important to consider. Too many complications will increase the child’s pain, affect further treatment, and increase the financial burden on the family. However, a complete surgery will relieve the parents’ mental burden, increase the confidence of the treatment, and of course, the doctor’s sense of accomplishment, and most importantly, improve the survival. Our “vascular skeletonization method” is a boon to children with neuroblastoma, as it increases the surgical resection rate and has very few complications.