Recently, we have seen several mothers-to-be in our clinic, all of whom showed emotional instability, emotional vulnerability, aggression, uncontrollable anger or crying when encountering the slightest thing, frequent panic attacks, chest tightness, and even persistent vomiting. Not only the pregnant woman herself is exhausted, but also the whole family will enter a state of irritability, anxiety and depression, which will lead to further aggravation of the pregnant woman’s symptoms. Prenatal depression is a new psychological disorder during pregnancy that has emerged in recent years and is on the rise year by year. Compared with postpartum depression, it is more harmful because of its more direct impact on the fetus. What are the reasons for the appearance of prenatal depression? First, because during pregnancy, the hormone levels in the pregnant woman’s body change significantly with the weeks of pregnancy, especially during the 6-10 weeks of pregnancy and before the end of pregnancy, which subsequently affects the release of neurotransmitters in the brain that regulate emotions, thus leading to changes in the pregnant woman’s emotional experience. In addition, the early pregnancy reaction in early pregnancy and the pressure of the uterus on the bladder and other organs in the second trimester, resulting in poor urination and sleep discomfort, can further aggravate the adverse emotional experience of pregnant women. Therefore, pregnant women may experience mood swings during these two stages even without external triggers. Therefore, pregnant women and family members need to understand the knowledge related to this issue to avoid unnecessary worries, and pregnant women themselves should accept their physical and psychological changes, while family members, especially spouses, should tolerate the possible emotional problems of pregnant women and give active attention and support. Secondly, psychosocial factors can push the pregnant woman’s mood in the direction of improvement or deterioration. Psychosocial factors play an important role in the regression of prenatal depression. The family support system surrounding pregnant women sometimes plays a dual role, presenting a supportive atmosphere by providing financial, material, human, and emotional support on the one hand, but sometimes, due to the complexity of family members’ relationships and the different intimacy between them, negative effects may be formed instead. For example, the more common family model nowadays is a small family model consisting of a husband and wife. In the process of welcoming a new life, it is possible that both spouses’ families of origin start to intervene in the small family, and if the previous closeness is not enough, then mutual adaptation can be a relatively large source of stress in this process. Therefore, at this stage, it is necessary for the whole family to realize that adaptation to each other needs to be a process, to be taken care of by relatives who feel closer to the pregnant woman, to divide the work and not to compare each other, thus providing a more relaxed family environment. From a pregnant woman’s psychological point of view, there may be several reasons for prenatal depression: some pregnant women may be unexpectedly pregnant and therefore feel unfamiliar and unrealistic about their role as a mother; others may be more dependent and egoistic in character, and psychologically refuse to grow up and assume the responsibility of being a mother. Because her husband wanted the child, but she was afraid that after having the child, her husband would only care about the child, therefore, she was in a contradictory psychological state all the time; in addition, she had bad expectations about the impact on her life after giving birth; some pregnant women may deal with real-life problems by repression, fantasy, avoidance, etc. before pregnancy, and after pregnancy, the increase in the number of real-life problems they face leads to the failure of the original ways. This may manifest itself through somatic discomfort, for example, in the form of pronounced vomiting or panic attacks or chest tightness. Therefore, helping pregnant women to discover the hidden stress and meaning behind their symptoms and assisting them to find better ways to deal with their problems will help them to spontaneously adjust their state. This part of the work requires the involvement of a professional psychotherapist. It is believed that through the joint efforts of families, pregnancy and childbirth will be both a challenging and arduous process as well as a happy and fulfilling one.