Depression manifests itself as symptoms of sadness, lack of interest, guilt, self-blame, and suicide, in addition to many other symptoms, pain being one of them. However, pain is the most overlooked and misdiagnosed or missed symptom in the diagnosis of depression. In this regard, psychiatrists call it painful somatic symptoms, and there are various terms used to describe such symptoms, such as chronic painful somatic symptoms, medically unexplained symptoms, and somatization symptoms. Just because patients present with symptoms of pain (back pain, headache, etc.), they are often seen in neurology, orthopedics, pain medicine, etc. This not only wastes medical resources, but also delays the patient’s condition and misses the opportunity for early diagnosis and treatment.