Patients with major depression stay at home every day and should be alert to the risk of self-injury, suicide and injury. Depression itself does not lead to the death of the patient, mostly due to suicidal behavior, and the exact length of time one can live is related to a variety of factors such as whether one receives standardized treatment and the caregiving environment. Depression is a common group of psychiatric disorders. If not treated, patients with major depression are likely to develop pessimism and anhedonia, and if not properly cared for, may create self-injury and suicide, posing a potential risk to the patient’s life safety. In addition, they may develop physical illnesses, such as diabetes, hypertension, cancer, etc., or aggravate existing physical illnesses. However, if patients receive scientific treatment as early as possible, the above-mentioned situations can be avoided and a cure may be achieved, which usually has no effect on survival and life expectancy is no different from that of normal people. Patients with major depression should be treated as early as possible, usually with medication first, and in the case that medication is not effective, twitch-free electroconvulsive therapy can be chosen to rapidly improve the state of major depression.