Depression is a common psychological disorder, mainly manifested by low mood, diminished interest, pessimism, slow thinking, lack of initiative, self-blame, poor diet and sleep, fear of suffering from various diseases, feeling unwell in many parts of the body, and in severe cases, suicidal thoughts or behaviors. The incidence of the disease is very high, almost 2 out of 10 adults suffer from depression, so it is also known as the mind flu. In China, only 5% of depressed patients are treated, and a large number of patients do not receive timely diagnosis and treatment, and their condition worsens and they even commit suicide. Delayed diagnosis and treatment of depression is very common, and many patients have already had one or more episodes before when they first visit the doctor, and most of them carry themselves through each time. In this group of patients, it is common that they or their family members are not aware of the disease or have a sense of stigma, which leads to delayed treatment. In addition, there are several specific types of depression that also cause delayed treatment: (1) insidious depression: depression with obvious somatic symptoms, where only somatic symptoms are noted and emotional problems are ignored, with digestive and cardiovascular symptoms and pain symptoms being the most common; (2) atypical depression: depressed mood with obvious anxiety and irritability, sleep, appetite, weight gain and a feeling of heaviness in the limbs; (3) menopausal depression: menopausal depression with anxiety and irritability. (3) Menopausal depression: depressed mood, anxiety, excessive fear of accidents, recalling the past with a pessimistic and negative mood, and comparing the present during menopause. Early diagnosis and treatment is one of the important factors that can improve the efficacy of depression. As the number of depression relapses increases, the duration of treatment increases accordingly, and with more than 3 relapses, it is recommended that lifelong medication is required. Therefore, enhanced recognition of depression is not only a mental health knowledge that every individual needs to know, but also a challenge for every clinician.