Moderate depression is a type of depression that generally develops for not less than 2 weeks, i.e., when depressive symptoms affect work, social or domestic activities and do not resolve for 2 weeks, it is called moderate depression. Depression is classified according to severity as mild depression, moderate depression, major depression and depression with psychotic symptoms. The symptoms of depression include 3 core symptoms (depressed mood, loss of interest and pleasure, and decreased energy) and 7 additional symptoms (impaired concentration, poor self-evaluation, self-guilt and feelings of worthlessness, pessimism about a bleak future, sleep disturbances, self-injurious or suicidal thoughts or behaviors, and decreased appetite). Moderate depression is defined as having at least 2 core symptoms plus at least 3-4 additional symptoms that do not resolve for 2 weeks. Patients with depression need to be treated with antidepressants in full dose and duration, together with psychological guidance, sufficient sleep and reasonable diet, which can help patients’ prognosis and even shorten the period of treatment.