Penile sclerosis is a disease characterized by connective tissue hyperplasia that occurs between the white membrane and fascia of the penile corpus cavernosum, also known as penile fibrous cavernositis, chronic penile cavernositis, and in Chinese medicine as penile phlegm nucleus . Penile sclerosis is common in men aged 30- 55 years. The causes are related to penile injuries (such as surgery, riding injuries, frequent sexual intercourse and excessive masturbation), chronic inflammation, atherosclerosis, tendency of muscle fibrosis (such as suffering from ankylosing spondylitis, cirrhosis of the liver, metaphyseal fibrosis), diabetes, vitamin E deficiency, alcoholism and taking certain drugs or injecting certain drugs into the penile corpus cavernosum. The lesions of penile sclerosis occur between the white membrane and fascia of the penile corpus cavernosum, and usually do not affect the urethra or adhere to the skin, but are mainly fibrous sclerosis of the affected area, and over time local calcification or ossification will form in the affected area. The main manifestation is the appearance of single or multiple oval-shaped plaques, or strips of hard nodules such as rice, soy or peanut size, with a texture like cartilage, on the dorsal side of the penile corpus cavernosum. The onset of penile sclerosis is slow, and in the early stages of the disease, patients hardly feel anything, and only occasionally have vulvar discomfort or a feeling of falling, so it is usually not easily detected at an early stage. When the penis is erect or during sexual intercourse, the inelasticity of the nodules hinders the normal erection of the penis, and the pulling of the hardened fibrous tissues leads to penile curvature and swelling pain. A small penile hardness has no effect on erection and does not interfere with sexual life. Larger hard nodes may hinder erection and cause the penis to be bent, causing swelling and pain. As patients have normal sexual function, erectile bending, painful erection, difficulty in intercourse or painful intercourse due to penile sclerosis, long-term inability to lead a normal sexual life, coupled with mental factors such as worry and anxiety, may result in mental impotence over time, which seriously affects sexual life. Some patients with sclerosis of the penis, due to the lack of understanding of the disease, taboo, did not go to the hospital in time for examination and treatment, and the lack of communication and understanding between the couple, suspicion, often affect the couple’s feelings, and even lead to marital crisis. The penile sclerosis has a certain self-limiting nature, the disease in the early stages of the slow self-healing characteristics, some in a few years may be hard nodes shrink, the symptoms of their own remission. Since there are more causes of penile sclerosis and relatively more treatments for the causes, you should undergo relevant examinations and treatments, such as active treatment of atherosclerosis, hypertension, diabetes, chronic inflammation, etc. Appropriate supplementation of various vitamins, moderate sexual life, no alcohol, avoid trauma to the penis, keep the local clean, underwear should be loose, soft has a positive preventive effect. Therefore: penile sclerosis is a benign lesion, its sclerosis does not involve the urethra, there is no pressure on the urethra, so it will not cause difficulties in urination, let alone cancer, so there is no need to panic.