Bone pain in leukemia patients is mainly due to the following two reasons: 1, leukemia patients with high tumor load, these patients often have abnormally high white blood cells, abnormally high white blood cells lead to bone pain, usually the nature of the pain is swelling pain, pain is usually more intense, the need to apply morphine and other drugs for pain treatment. The pain is usually more intense and requires the application of morphine and other drugs to relieve the pain. At this time, we only need to stop using the granulocyte colony-stimulating factor and give pain treatment, and the bone pain will be relieved as the granulocyte colony-stimulating factor is stopped.