Syphilis rash can be distributed all over the body. Syphilis rash is a specific symptom of syphilis stage II. The mucosal manifestations of stage II syphilis rash are more extensive, symmetrical in the early stage and polymorphic later on, and there are also rashes that are confined, with mild self-conscious symptoms, less destructive and highly contagious. The most common symptoms of second-stage syphilis rash include macular rash, maculopapular rash, papular rash, papular syphilis rash, follicular rash, yaws-like rash, pustular rash, ulcerated rash, etc. The beginning of the damage is macular rash, which occurs 5-8 weeks after hard chancre, distributed on the trunk and flexors of the limbs, round or oval, rose-colored, 0.5-1 cm in diameter, and fades after a few days. The most common rash is a maculopapular rash, which occurs 2-4 months after infection and is distributed all over the body, including the face, trunk, and flexors of the extremities, coppery red, and palm and finger areas. The rash is characteristic and the papules are also the most common in the second stage syphilis rash, less numerous than the maculopapular rash, copper-red, flattened or spike-like at the tip, smooth surface, distributed on the palms and toes, trunk, upper and lower extremities and face, some rashes are disseminated or generalized, some rashes are isolated, and disseminated rashes form a ring or arch.