Syphilis is transmitted through blood, sexual intercourse and close living contact. It can be treated if found in time, but it must be treated thoroughly enough. Sexual contact transmission accounts for 95% of total transmission, mainly through sexual intercourse or other sexual behavior, such as homosexuality, kissing, etc. Untreated patients are the most infectious within 1 to 2 periods of infection. Patients in the first and second stages are found on the mucosal surface of the skin in the genitals and other areas, and also in body fluids such as saliva, semen, breast milk, urine and blood. Direct transmission can be caused by kissing, breastfeeding, gynecological examination, direct contact with the patient’s skin lesions, contaminated objects and utensils, such as contact with contaminated clothing, towels, eating utensils or contaminated medical equipment. Indirect transmission can occur through the birth canal, where a newborn baby is born with a head or shoulder injury, comes into contact with the mother’s genitals, is infected with spirochetes from the mother’s pubic area, and causes acquired syphilis in the baby. Blood-borne transmission: If the blood donor is a patient with latent syphilis, he or she may have syphilis spirochetes in his or her blood, which can be transfused into the recipient’s body and cause infection. Transmission through the placenta. If a pregnant woman is an untreated syphilis carrier, the entire course of the disease can be transmitted to the fetus through the placenta. The treatment of syphilis should follow the basic principles, which can be done through early detection, early treatment, adequate amount and full course of treatment, and the early stage is the best time for treatment.