Aminotransferases are catalytic enzymes essential to the metabolism of amino acids in the body. ALT is widely found in the liver, heart muscle, skeletal muscle, kidney and other tissues, and is most abundant in the liver cells. AST is mainly found in the heart muscle, followed by the brain, liver and kidney. AST in the liver is mainly found in the mitochondria of hepatocytes, and will be significantly increased when the liver is severely necrotic or damaged. If elevated aminotransferases are found during a physical examination, we should neither panic nor take it lightly, but treat it rationally and analyze the cause of the elevation. We generally consider transaminases to be moderately elevated if they are more than two times the upper limit of normal values. Moderate to severe elevation of transaminases indicates serious damage to liver cells, mostly due to hepatobiliary diseases, such as various types of viral hepatitis, cirrhosis, alcoholic liver disease, drug-related hepatitis, cholangitis, autoimmune hepatitis, parasitic infections, etc. It is necessary to check hepatitis virus markers, autoantibodies, parasite antibodies and hepatobiliary ultrasound and other related tests to clarify the cause and treat the symptoms. If the transaminases are less than 2 times the upper limit of normal value, it is considered mildly elevated. There are many reasons for mild elevation, mainly the following: 1. alcoholism. 2, malnutrition. 3.High fever. 4.Other organ diseases. 5, Strenuous exercise, menstruation and other physiological states can also cause a transient increase in aminotransferases. As the result of transaminase test is often affected by the body’s own state, the quality of the test personnel, the machine and other factors, if only one test result found a mild increase in transaminase, it is best to repeat the test once to avoid experimental errors. Most people with mildly increased aminotransferases can recover to normal levels as long as they remove the cause, pay attention to rest, and supplement with some enzyme-lowering and liver-protecting drugs such as Ganixin capsules and Pendleton grass punch.