The wasp (Vespoidea) is a member of the Hymenoptera suborder of insects, also known as hornets, wasps, grass wasps, etc. There are about 5,000 species of wasps known worldwide. The toxins of wasps include biogenic amines (such as histamine and dopamine), kinins, mast cell degranulation polypeptides, neurotoxic proteins, phospholipase A2, hyaluronidase, etc. After being stung by wasps, local wounds can be painful, red, swollen, papular and erythematous, or black nailhead-like necrotic lesions, which can be accompanied by damage to the circulatory system, nervous system, urinary system and other systemic damage, and severe poisoning can be fatal. The general performance of wasp stings (a) the performance of the sting site: stings appear painful, swelling, 12-48 hours to aggravate the spread of the expansion, can be ulcerated to form ulcerated surface of different sizes. (b) Allergic reactions: appear minutes to hours after the sting, manifesting as a rapidly expanding rash, suffocation, dyspnea, nausea and vomiting, and in some patients, diarrhea. Anaphylactic shock can occur in some cases and is a major cause of early death. (iii) Hemolysis: urine is tea-colored to soy sauce-colored, lumbago, renal function changes, and later may show varying degrees of anemia. (iv) kidney injury: can be caused by the direct action of toxins on the renal tubules or by hemolysis, manifested as general edema, oliguria, and changes in renal function. (v) Liver injury: mostly due to immune complex deposition resulting in hepatocyte necrosis, manifested as liver injury-related elevation of serum enzymes. (F) neurological and cardiovascular effects: the changes caused by different toxins are different. (3) General treatment principles (a) Local treatment: wasps do not leave stings in the body, bees may leave stings in the body. If there is a stinger, apply a sticky tape to remove it and rinse thoroughly with water. Ice packs are effective in reducing local reactions. For severe allergy, 0.1% epinephrine 0.5ml can be injected subcutaneously. Topical application of water-adjusted Jidexam snake medicine can be applied. (b) Adrenal glucocorticosteroids: used when there is a serious allergic reaction, hemolysis, other effects on bee stings also have a mitigating effect. (iii) Hemopurification therapy: Blood perfusion can better remove toxins from the blood. In severe cases, 2 consecutive instances of perfusion therapy are possible. （The main prevention methods Summer and autumn are the seasons when hornets are more active, and they are mostly found in areas where plants are abundant in the field. If you meet with a swarm of bees, you should avoid it as soon as possible and do not take the initiative to beat or drive it away. Once you have attracted a swarm of bees, take protective measures immediately, such as hiding in a building, closing doors and windows, getting down on the ground to reduce the exposed area, covering your body with clothing or other membranes, and especially protecting your face, hands and other exposed parts. If you are stung by a bee, check for poisonous stings in the skin, remove the stings and flush the wound with water. Do not touch the hornet nest by non-professionals. V. Principles of critical care (a) Patients with the following conditions can be initially assessed as critical and need to be admitted to hospital as soon as possible. Unstable vital signs; organ dysfunction, requiring close monitoring and/or organ function support treatment; serious underlying disease, bee stings or their complications may affect the treatment of the underlying disease. (B) Evaluation of the functional status of each organ system. 1.The sequential organ failure score (SOFA) system is recommended to evaluate cardiovascular, respiratory, coagulation, hepatic, central nervous system and renal functions (Table). 2. Evaluate other manifestations of the functional status of the organ system. Various types of arrhythmias affecting circulatory function; disseminated intravascular coagulation (DIC); rhabdomyolysis and myoglobinuria; upper gastrointestinal bleeding.