Patient Question: Doctor? Why can’t my condition be stabilized even though I’ve been taking medication? The disease: depression Description of the disease (main symptoms, onset time): After a year of 04 to 05 years of career and relationship of the dual unhappy, from the end of 05, slowly symptoms have been manifested, intermittent time will be so a week for ten days, people have no spirit, no energy, do not want to do anything, and do not want to contact with people, but also feel particularly depressed, and more resistant to people, always love to be alone, the brain is slow, and simple communication with people is also very difficult. Depressed, also more resistant to people, always love to be alone, brain reflection is also relatively slow, and simple communication is also very difficult, for the outside world seems to have little feeling, and the main thing is that the mood is particularly low, that period of time is the above kind of feeling, at that time they did not care, that period of time lasted, the whole person will be completely back to normal, good for a long time, that bad state again From 2007 to 2009, I had been taking antidepressants for two years, including Celete, Prozac, venlafaxine, and so on, but I still couldn’t control my condition and stabilize it. The doctor asked me to change my medication to one tablet of sertraline and one tablet of magnesium valproate in the morning and one tablet in the evening every day, and then relapsed after less than a month. In the past few years, the life and work of people messed up. The key is not good when there is no way to work, normal time is okay, work life is not affected. In a, I seem to feel no special happy when normal, especially good and excited kind of feeling, is bad and good between the old cycle, good for a while, bad for a while! Previous treatment and effects: take medicine, can not control the condition Wanted to get what kind of help: how to treat to make the condition stable. Guangzhou Brain Hospital Psychiatric Department Jiang Zeyu: The treatment of depression is a highly specialized technique, and you must turn to a doctor with a certain level of expertise in order to achieve better treatment results. If depression is diagnosed, the main treatment options include medication, systematic psychotherapy and electroconvulsive therapy. Among them, medication is the main treatment option. You should be patient with medication and should not change the type of medication frequently. It is possible that the doses of the two medications you are currently taking are insufficient. It is recommended that the dose of medication be adjusted by the doctor with reference to the blood concentration of the two related drugs. After the adjustment, if it is effective, you may need to adhere to the medication for a longer period of time, taking into account your condition and treatment history. Do not reduce or change the medication at will. If it is not effective, you may consider adding a booster. Patient: Doctor, I paid special attention to my relapse this time. I have been taking antidepressants, but I started to relapse again in the first four or five days, I didn’t want to do anything, I didn’t like to move, I wanted to sleep all the time, I felt that it was difficult to communicate with people, I couldn’t use my brain, I was repulsed by the outside world, I was particularly depressed, I had no emotions towards the outside world, I had all the symptoms of depression, in the days of relapse. I stopped taking the medication for two days, and then took the same amount of medication as before, and by the next day, all the symptoms were gone, and there were two people before and after. I was seriously thinking that the antidepressant medication, which has lasted for two years in our area without interruption, still has a high frequency of relapses, and now I still relapse almost once a month, could it be something other than depression? A doctor listened to my situation and said it was a bit like schizophrenia, I don’t know now, get rid of the doctor to give me some advice? I’ve been in a constant cycle between normal and depressed these past few years. Guangzhou Brain Hospital psychiatric department Jiang Zeyu: You need to rule out the possibility of bipolar depression. It is recommended to use mood stabilizers in sufficient quantity in combination with blood concentration monitoring, and on this basis, use antidepressants as little as possible to circumvent the risk of faster cycling.