First of all, there are two specific test indicators for syphilis, the majority of hospitals check RPR and TPPA: RPR: the full name is “rapid plasma reactin ring card test”, is a diagnostic screening test for syphilis, the test list is expressed in titers (negative, 1:1, 1:2, 1:4, 1:8, 1:16, 1:32, etc.). The higher the titer, the more serious the syphilis can be), used to observe the effect of treatment and determine the recurrence and reinfection; similar methods are also available for TRUST, etc. TPPA: The full name is “syphilis spirochete agglutination test”, used to determine the diagnosis, but not for screening and observing the effect of treatment. Similar methods include TPHA, etc. The syphilis test is a combination of RPR and TPPA with a negative result, but this is not a simple mathematical combination, and its interpretation needs to be considered in the light of the patient’s condition. The following is a brief explanation of the meaning of some combinations: the patient has a typical second-stage syphilis rash, the test results RPR (+, here should be marked titer), TPPA (+), can be fully diagnosed as second-stage syphilis, timely treatment it; patients have typical syphilis and given a full amount of full course of penicillin treatment, thereafter should focus on checking RPR and observe titer changes, most people two years to negative, some people continue for life and remain low. Most of them become negative in two years, some of them remain low titer for life, but almost permanently positive for TPPA in life. If the RPR titer is high, such as 1:64 or 1:128 or 1:256 or higher, in order to prevent the occurrence of high fever and chills caused by the immune hyperactivity of the body due to the disintegration of the spirochete caused by penicillin, the doctor will generally prescribe prednisone orally for 2-3 days before treatment (do not consider hormones at this time). Sometimes the typical stage I syphilis, but the laboratory test results suggest that the test results RPR (-), TPPA (-) or RPR (-), TPPA (+), then you need to recheck after 4 weeks will generally RPR (+). If the typical phase I syphilis, at this time should also provide treatment; If the occasional laboratory results are RPR (-), TPPA (+), indicating two situations 1, early syphilis; 2, once treated has been cured; 3, once had syphilis, but they do not know but due to their own resistance to great completion of self-treatment, cured; at this time should be rechecked after 4 weeks, if RPR turns positive that has syphilis, if still RPR negative, it means that is their own great. If occasionally the test result is RPR(+), TPPA(-), most of them are false positive at this time, including laboratory error, autoimmune disease, leprosy, heroin addiction, a few pregnant women and the elderly; if the test is still RPR(-) and TPPA(-) 10 weeks after unclean intercourse -All suspected syphilis should be tested for HIV and all confirmed syphilis partners should also be tested for syphilis and HIV; it is too difficult to interpret the tests for syphilis in pregnant women and congenital syphilis in infants, interpret them carefully and treat them promptly!