There are two main types of drugs for men who do not last, including topical local anesthetics, and oral selective 5-hydroxytryptamine reuptake inhibitors. Male non-persistence mostly refers to male premature ejaculation, which is mainly caused by increased penile sensitivity, lower ejaculation threshold and weakened control of ejaculation. If the patient’s premature ejaculation is caused by increased penile sensitivity, it can be improved by using local anesthetics. If it is caused by a lowered ejaculatory threshold and weakened control of ejaculation, it can be improved by using oral medication. However, it should be noted that whether using topical or oral medications, they should be used under the guidance of a specialist physician and should not be used blindly without authorization to prevent adverse consequences. In addition, poor mental state, excessive psychological stress and prostate disease may also be the cause of premature ejaculation. If the patient is caused by psychological factors, it is not recommended to take medication blindly, pay attention to the psychological adjustment can be. If it is caused by other diseases, the original disease should also be actively treated.