Recently, our Hepatobiliary Surgery Department successfully completed the first transumbilical single-port laparoscopic cholecystectomy + hepatic cyst opening in South China, achieving another leap in the application of laparoscopic surgery technology and marking that our hospital continues to be at the forefront in South China in the use of laparoscopy. The female patient, a white-collar worker in a company, just turned 30, came to our hospital for laparoscopic surgery after learning about Prof. Chen Yajin, director of our hepatobiliary surgery department, on the Internet after suffering from gallbladder stones and liver cysts. After the preoperative evaluation, Prof. Chen Yajin found that she was physically fit for the transumbilical single-port laparoscopic surgery and was overjoyed to learn that she could be completely scar-free and could continue to wear a bikini after the surgery. The surgery went very smoothly and took only 40 minutes to complete. The patient was discharged the next day. Since the wound was closed with a special wound adhesive, there was no need to remove stitches after the surgery. The patient did not feel any pain due to the low tension in the lower abdomen and the dullness of pain, so no postoperative analgesia was needed. She returned to the hospital recently for a review and the results were very satisfactory. The single-port laparoscopic technique, which was named one of the top 10 medical innovations in the United States in 2009, is the most cutting-edge minimally invasive technology in the world. During the surgery, surgical instruments and equipment enter the abdominal cavity through the umbilical port, using the umbilical crease wall to conceal the surgical incision, with no obvious scars on the body surface. The cosmetic effect is obvious and meets the modern requirements for quality of life. The single-hole laparoscopic technique is another leap in the concept of minimally invasive surgery and places higher demands on the surgeon. While the previous four-hole and three-hole classical laparoscopic surgical approaches used the space between the angle of the operating instruments placed in different parts of the abdomen to accomplish this, the single-hole laparoscopic technique increases the difficulty of the operation because the laparoscope and the operating instruments are in parallel positions and the angle becomes zero, requiring the surgeon to have a more skilled microscopic operation technique.