Application of common hepatoprotective drugs

  Liver-protective drugs are drugs that have a certain protective effect on liver cell damage. There are many causes of liver cell damage, therefore, in liver-protective treatment, the causes should be removed first, and then liver-protective drugs should be administered in order to be effective. In addition, the liver is a detoxification organ, try to use as few drugs as possible. If the key to chronic viral hepatitis is antiviral therapy, drug-related liver disease should immediately stop the drug in question or suspected and promote the clearance of the drug in the body. Commonly used hepatoprotective drugs are introduced as follows: 1, essential phospholipids: an important component of the cell membrane, promote hepatocyte membrane regeneration, coordination of phospholipid and cell membrane function, reduce fat infiltration, such as polyphosphatidylcholine (EzanFu). It is rapidly absorbed by oral or intravenous administration, metabolized by the liver and mostly used by the body, and the metabolites are excreted in urine. Contains benzyl alcohol, prohibited in newborns, and used with caution in the first 3 months of pregnancy. Adverse reactions are rare, oral doses can lead to diarrhea, and very few allergies.  2, detoxification drugs: can provide sulfhydryl group or glucuronide to enhance detoxification function, such as glucuronide, glutathione, thioprostenol. Reduced glutathione is mainly synthesized in the liver and widely distributed in various tissues and organs. It freely combines with peroxides and free radicals in the body, and protects the proteins and enzymes containing sulfhydryl groups in the cells against the destruction of sulfhydryl groups by antioxidants, and against the destruction of sulfhydryl groups by antioxidants, and protects the proteins and enzymes containing sulfhydryl groups in the cells against their damage to the organs. Thiopronine can provide sulfhydryl groups, detoxify, antihistamine and scavenge free radicals to protect liver cells.  3.Anti-inflammatory drugs: have hormone-like effects, mainly glycopyrrolate sweetener preparations.  4.Biliary drugs: adenosylmethionine is the active substance in all body fluids, as a precursor provided by methyl to participate in important biochemical reactions, in the liver to help prevent bile stasis. Ursodeoxycholic acid is an isomer of normal bile components, which can increase bile secretion, inhibit hepatic cholesterol synthesis, reduce liver fat, relax the sphincter of Oddi, promote gallstone dissolution and bile discharge, but severe hepatic insufficiency, biliary obstruction is prohibited, and pregnant and lactating women should be used with caution.  5, biological agents: such as hepatocyte growth factor. Promote hepatocyte regeneration, mostly used for severe hepatitis.  6, enzyme-lowering drugs: all intermediates in the synthesis of pentosidine, the induction of cytochrome P450 enzyme activity, thereby strengthening the detoxification of carbon tetrachloride and certain carcinogenic substances. Commonly used varieties include biphenyldiphenhydramine (Bicenor) and bicyclic alcohol tablets. Because the effect on aspartate aminotransferase is not obvious, some scholars believe that there is no hepatoprotective effect.  7, vitamins and coenzymes: can promote energy metabolism, to maintain the normal activity of various enzymes required for metabolism, mainly including a variety of water-soluble vitamins, such as vitamin C, vitamin B and coenzyme A, etc.. Fat-soluble vitamins in large doses, may increase the burden on the liver, generally not used.  8, promote energy metabolism: adenosine triphosphate, can provide the body with the required heat and participate in the body’s sugar, fat and protein metabolism. Coenzyme A, plays an important role in sugar, fat and protein metabolism, and is also commonly used in clinical practice. Inosine, which can directly enter the cells, participate in intracellular energy metabolism and protein synthesis, promote liver cell repair and regeneration, and can restore the function of damaged liver cells.  9, Chinese herbal medicine: the traditional medicine of the motherland has unique features for the treatment of acute and chronic liver disease, Wu Wei Zi, Yin Chen, pendula and other drugs have obvious efficacy in protecting the liver and lowering enzymes, many formulas are safe and effective, clinical application is very wide, such as Yin Gardenia Huang, bitter ginseng base, etc.