Syphilis chancre is a symptom of stage I syphilis, which is a localized vulvar or perianal skin lesion that develops within 30-60 days after the human body is infected with the syphilis spirochete. This condition mainly presents as a cartilaginous ulcer without any conscious symptoms. When the surface of the ulcer is touched by hand, the hard texture of the muscle base can be felt, which is the clinical appearance of the local skin surface formed by the syphilis spirochete. The condition is highly contagious, and if left untreated will subside on its own in about 60 days, then enter the asymptomatic incubation period, and then enter syphilis stage 2 when it reoccurs. Treatment with long-acting penicillin is required. After 21 days of continuous treatment, the drug is discontinued and observed for 90 days, after which the syphilis titer is checked again and compared with the titer at the time of diagnosis to evaluate the efficacy of the drug treatment.