Laboratory and special tests for hepatomegaly: 1, white blood cell count and classification: high white blood cell count or and neutrophilia are seen in liver abscess, sepsis, etc.; hypocytosis is seen in typhoid fever, malaria, black fever and viral infections; eosinophilia is seen in schistosomiasis and hepatic echinococcosis, etc. 2, liver function tests: a wide variety, AST, ALT increase suggests acute hepatitis or chronic hepatitis active; protein metabolism disorders mostly reflect chronic diffuse liver injury; lower clear protein, elevated globulin, especially protein electrophoresis shows elevated γ-globulin is useful for clinical judgment of chronic liver disease, especially the accompanying immune response; changes in bilirubin metabolism is helpful to distinguish the nature of jaundice. It should be noted that extrahepatic diseases may also have liver function abnormalities, while limited liver lesions may not have liver function impairment. 3, viral hepatitis antigen, antibody system testing: helpful to determine the type of viral hepatitis and determine its infectiousness. 4.Detection of various tumor markers: increased AFP has important diagnostic value for primary liver cancer. Its heterogeneous body test, rocket alglucosidase and abnormal prothrombin test are also helpful for the diagnosis of hepatocellular carcinoma. 5.B-type ultrasonography: it can help to determine the degree and outline of hepatomegaly, whether there are intrahepatic occupying lesions and the nature of lesions. 6.X-ray examination: plain film can determine the location of the right diaphragm and the size of the liver; CT can determine intrahepatic occupying lesions, which has important diagnostic value for hepatocellular carcinoma, hepatic hemangioma and hepatic cysts. 7.MRI: It can provide more important diagnostic value for intrahepatic vessels, portal blood flow and the signal shown by tiny occupying lesions. 8.Hepatic aspiration and biopsy: it can provide histological diagnostic basis for large liver that cannot be diagnosed by conventional examination, and it is safer and more reliable when performed under B-type ultrasound mediation or laparoscopy. 9, laparoscopy: the size, color and lesions of the liver can be observed, which is of great value in the diagnosis of primary liver cancer, metastatic liver cancer cirrhosis and liver macrosomia of unknown cause. Biopsy under direct vision can be more targeted than blind liver activity examination, and the positive rate is higher, and it can also determine whether to make a dissection or whether the tumor can be removed.