The ultimate goal of chronic kidney disease treatment is to protect the kidney function. Therefore, in addition to various treatment measures, the most important thing that patients with chronic kidney disease should do is to resume normal living and eating habits to avoid additional damage to the kidneys as much as possible. Adequate sleep is an important part of ensuring the normal physiological function of human organs. Staying up late for a long time is a chronic damage to both the physiological function of the kidneys and the function of other organs, and we hope that patients with chronic kidney disease will pay attention to this important aspect. I. Medical Pulse Introduction The McMullan CJ research group at Brigham and Women’s Hospital studied the correlation between sleep duration and the decline in kidney function, and the results showed that sleep deprivation was significantly associated with a rapid decline in kidney function. The findings were published in Kidney International. Most renal physiological functions have circadian rhythms, such as regulation of the renin-angiotensin system, sodium reabsorption, renal blood flow, glomerular filtration rate and filtration fraction; similarly, 13% of all gene transcription in the kidney occurs during the day. There is growing evidence that altering both the duration of sleep and the time to sleep affects renal function. Sleep deprivation and night shifts are associated with chronic kidney disease (CKD) risk factors such as hypertension, diabetes and cardiovascular disease. Cross-sectional studies have shown that patients with kidney disease have a shorter average sleep duration. A prospective study in Japan showed a 70% increased risk of proteinuria in those who slept ≤6 hours per night compared to those who slept 7 hours per night. A total of 4238 women whose blood creatinine was measured from 1989-2000 were included in this prospective study. The mean age was 58.0 years (±6.6 years), the mean body mass index was 25.8 kg/m2 (±5.1 kg/m2), and the mean estimated glomerular filtration rate (eGFR) was 88.3 ml/min/1.73 m2 (±25.0 ml/min/1.73 m2). 9.7% of the women had diabetes, 28.7% had a history of hypertension, and 3.8% had a history of cardiovascular disease. history of cardiovascular disease. Mean sleep duration was 7 h (6-8 h, 25th-75th percentile). Subjects who reported sleeping ≤5 h per night had a higher prevalence of body mass index, diabetes, hypertension, and cardiovascular disease than those who slept 7-8 h per night. The follow-up period was 11 years. After correction for age, the ratio of rapid decline in renal function was 1.91 (95% confidence interval [CI] 1.27-2.88, P = 0.002) in subjects with ≤5 h of sleep compared with those with 7-8 h of sleep per night, and 1.30 (95% CI 1.05-1.60, P = 0.01). After adjusting for age, systolic blood pressure, body mass index, eGFR, smoking status (smoker, former smoker, nonsmoker), history of hypertension, history of diabetes, history of high cholesterol, acetaminophen use, and use of drugs with reversible effects on renal function, the ratio of rapid decline in renal function in subjects with sleep duration ≤5 h was 1.79 (95% CI 1.06 -3.03, P = 0.03) The ratio of rapid decline in renal function in subjects with 6 h of sleep was 1.31 (95% CI, 1.01-1.71, P = 0.04). After further correction for night shift, the results were unchanged (OR = 1.75, 95% CI 1.04-2.96, P = 0.04). 4063 subjects with normal kidney function at baseline had a CKD incidence ratio of 1.95 (95% CI 1.16-3.30, P = 0.01) for subjects with sleep duration ≤5 h, after complete correction. The CKD incidence ratio for subjects with 6 h of sleep was 1.18 (95% CI 0.90-1.54, P = 0.24). Those who slept 7-8 h per night had the slowest rate of decline in renal function, with eGFR decreasing by 0.9 ml/min/1.73 m2 per year (±1.7 ml/min/1.73 m2/year)-significantly less than those who slept 6 h (eGFR decreased by 1.1 ± 3.4 ml/min/1.73 m2 per year, P = 0.009). The fastest decline in renal function was observed in those who slept ≤5 h (eGFR decreased by 1.3 ± 2 ml/min/1.73 m2 per year). After correction for age and multivariate factors, the results were unchanged, and the increased rate of decline in renal function was significantly associated with sleep deprivation (corrected P = 0.008). The incidence of proteinuria was twice as high in those who slept ≤5 h per night as in those who slept 7-8 h (corrected OR = 2.52; 95% CI 1.42-4.49, P = 0.002), and multivariate model analysis showed that sleep deprivation was significantly associated with an increased incidence of proteinuria (P = 0.002).