Hepatitis B virus “conversion” is divided into three stages; the first step is to make the genes of the hepatitis B virus (HBV DNA) negative; the second step is the seroconversion of the hepatitis B virus e antigen, that is, the disappearance of the e antigen and the appearance of the e antibody; and the third step is the seroconversion of the surface antibody (the disappearance of the surface antigen and the appearance of the surface antibody. The third step is surface antibody seroconversion (surface antigen disappears and surface antibody appears.) By the third step, it can be said that hepatitis B is completely cured. However, it is still difficult to realize the goal of the third step with the existing therapeutic drugs, and the patients who can reach the third step only account for a small part of the hepatitis B patients. However, if the second step is achieved (and maintained for a long time), the liver cells can be protected from virus-induced immune damage, thus maintaining the long-term stability of liver function, in other words, it will not develop into cirrhosis, hepatocellular carcinoma and other end-stage liver diseases; in order to achieve the above treatment goals, it is necessary to adhere to the regular antiviral therapy.