1.Large nodules with clinical symptoms such as gas pressure, swallowing, hoarseness, etc.; 2.Imaging tests such as ultrasound or CT suggesting retrosternal goiter; 3.Large nodules affecting appearance and normal life and work; 4.Nodular goiter (often referred to as “nodular nail”) with secondary hyperfunction (often called “5. suspected malignant changes (e.g., ultrasound suggests rich blood flow, calcification, ECT suggests cool nodules, etc.); 6. diagnosed as thyroid adenoma.