(Disclaimer: This article is only for popularization of science, in order to protect the patient’s privacy, the relevant information in the following content has been processed) Abstract: The patient is a 43-year-old male, recently always feel weak, abdominal distension, dull pain in the liver area, in the process of talking with the patient, found that the patient has the habit of drinking alcohol for 20 years, and drinking higher degrees of white wine. Through liver function, ultrasound, physical examination and other aspects, finally diagnosed as “alcoholic liver disease, splenomegaly, cholecystitis”. The patient was given medication, and after treatment, his general condition improved significantly and his liver function gradually recovered. Basic information] Male, 43 years old [Type of disease] Alcoholic liver disease, splenomegaly, cholecystitis [Hospital] The Second Affiliated Hospital of Harbin Medical University [Date of consultation] February 2022 [Treatment plan] Medication (Reduced Glutathione for Injection, Diisopropylamine Dichloroacetate Tablets, Polyenphosphatidylcholine Capsules, Pantoprazole sodium enteric-coated tablets) [Treatment cycle] Hospitalization for 10 days with regular follow-ups. [Treatment effect] The patient’s general status improved and liver function gradually recovered I. Initial consultation The patient, Mr. Hao, came to the clinic with uncomfortable symptoms that had already lasted for one month, mainly fatigue, abdominal distension, and also felt a dull pain in the liver area. I carefully looked at the patient’s overall state: dark color, large stomach, thin limbs, and obvious abdominal obesity. Subsequent examination: the patient’s epigastric bulge, high under the raphe, mobile turbidities negative, without a large amount of ascites, the stomach did not have obvious pain on pressure. Understanding the history of the patient, he found that he had been drinking alcohol for more than 20 years, and most of them were highly alcoholic beverages, more often than not reaching more than half a kilogram. The patient had no other related diseases, no long-term medication, no special circumstances such as eating raw fish, no family history of liver disease. 5 days ago, he went to the hospital and found that his liver function was abnormal, and he came to our hospital for further examination after taking 5 days of hepatoprotective tablets with no obvious relief of his symptoms. According to the medical history, alcoholic liver disease was considered, but it was necessary to do exclusionary diagnosis, and the patient also wanted to be hospitalized to adjust the physical state, so he was admitted to the hospital. After admission, the patient was given a complete and relevant examination, and the glutamyl transpeptidase was 275.4 U/L; other hepatitis series and liver autoantibodies were negative; ultrasound found hepatomegaly, splenomegaly, and hairy walls of the gallbladder, and the final diagnosis was alcoholic liver disease, splenomegaly, and cholecystitis. (Biochemistry checklist) (Doppler checklist) II. Treatment During hospitalization, the patient still felt dull pain in the liver area and poor appetite, and was told that the patient needed to improve his life style in the long term by absolutely abstaining from alcohol and avoiding liver-damaging drugs. However, the patient kept asking me if it was okay to drink less because he did not want to affect his work socialization. I informed the patient that there was no safe dose of alcohol to drink in the current situation and that he could only abstain from alcohol absolutely. Otherwise, the liver disease would progress further, and if not well controlled there was a risk of progression to cirrhosis, or even complications such as ascites and gastrointestinal bleeding, which the patient understood. In addition to the necessary information, for epigastric discomfort, poor appetite and intermittent nausea, pantoprazole sodium enteric-coated tablets are given for symptomatic treatment. At the same time, hepatoprotective treatment was given, using reduced glutathione for injection, compound diisopropylamine dichloroacetate tablets, polyene phosphatidylcholine capsules and so on. The patient’s symptoms were significantly relieved after 1 week of treatment. After repeated communication about his condition, the patient’s psychological pressure was reduced and he also decided to quit drinking completely. The patient’s face had obvious improvement with some blood color, and the symptoms of nausea and anorexia disappeared, so he stopped using pantoprazole sodium enteric-coated tablets. The patient’s liver function was rechecked, and it was found that the glutamyl transpeptidase was reduced, changing to 180 U/L. The patient was continued to be given hepatoprotective therapy for 1 week, and when rechecked in the 2nd week of hospitalization, the glutamyl transpeptidase was reduced to 120 U/L, and the patient was discharged from the hospital. The patient was discharged, and was instructed to have a review every 2 weeks to 1 month or so thereafter, and a liver ultrasound review was recommended every 3 months to 6 months. Fourth, the precautions are very glad that the patient after treatment, the body discomfort symptoms reduced. Patients need to pay attention to the fact that alcoholic liver disease is a long-term, chronic process, and lifelong abstinence from alcohol is required after discharge from the hospital in order to control the development of the disease. If the liver function is normalized and then drink, so repeatedly, the disease can not be controlled, and will eventually lead to cirrhosis or even liver cancer. Meanwhile, it is also important to improve the lifestyle. In addition to drugs to avoid liver damage, diet, low oil, low salt, low sugar, more fresh vegetables and high-quality proteins, and usually moderate exercise to enhance physical fitness. V. Personal insights Alcoholic liver disease currently lacks specific diagnostic criteria, therefore, it is necessary to combine the patient’s past history of alcohol consumption, liver disease and family history to make a comprehensive diagnosis, and to exclude other common causes of liver injury, such as hepatitis B, hepatitis C, and self-exempted liver. Patients with alcoholic liver disease, such as this patient, often have a history of heavy drinking, abdominal obesity, and in some cases, decreased muscle mass, and may have an appetite that is affected by heavy drinking. Therefore, drinkers should have regular physical examinations, review liver function and liver ultrasound; for patients who have been diagnosed with alcoholic liver disease, they need to develop a comprehensive treatment and review program, and carry out hepatoprotective and anticirrhotic treatments according to liver function.