Spontaneous Intracranial Hypotension (SIH) is a congenital disorder in which there is no specific cause (e.g., craniocerebral trauma, spinal puncture, etc.) for a decrease in cerebrospinal fluid pressure or volume (hence the term cerebrospinal fluid hypotension); postural headache is its main clinical manifestation, i.e., headache occurs in the sitting or standing position and is relieved or completely relieved after lying down. In addition to postural headache, other clinical manifestations include cervical tonicity, vomiting, vertigo, blurred vision, visual field defects, diplopia, tinnitus, hearing loss, declining Parkinson’s syndrome, ataxia, frontotemporal dementia, and even coma. death, etc. Patients with lumbar puncture have reduced or zero pressure; some patients have normal pressure; cranial MRI shows: downward displacement of brain tissue, dural enhancement and subdural effusion or hemorrhage. Epidemiological data show that the annual incidence of SIH is 5/100,000, with a peak age of about 40 years and a male to female ratio of 1:2. The etiology and pathogenesis of spontaneous intracranial hypotension are becoming clearer, and some patients with SIH are associated with connective tissue diseases; some connective tissue diseases such as Marfan’s syndrome and autosomal dominant polycystic kidney are prone to spontaneous intracranial hypotension due to cerebrospinal fluid leakage. Regarding the cause of spontaneous intracranial hypotension, it is generally believed that spontaneous intracranial hypotension is related to cerebrospinal fluid leakage, and cerebrospinal fluid leakage is related to structural weaknesses of the spinal membrane, including diverticula of the spinal membrane, tiny tears of the nerve root sleeve and Tarlov cysts (neurogenic sleeve cysts). This rupture can be determined by radiocerebral pool imaging, MRI hydrography, MRI or CT imaging to determine whether there is cerebrospinal fluid leakage or leakage from the segment, which can be used not only to help diagnose the disease but also to guide the intraoperative localization of interventional procedures. Cerebrospinal fluid leakage and reduction in cerebrospinal fluid volume leads to sinking of brain tissue, and this sinking leads to stretching and distortion of various pain-sensitive structures within the skull, resulting in hypocranial pressure headaches, and dilatation of intracranial veins and venous sinuses also play a role in the mechanism of headache production. Cerebrospinal fluid leakage can occur anywhere in the dura mater, but it is more likely to occur in the cervical segment or at the cervicothoracic junction, accounting for approximately 80% of cases. For a long time after the discovery of SIH, treatment of SIH was limited to conservative medical therapy, including bed rest, massive fluid replacement, intravenous caffeine or theophylline, corticosteroids, and lap banding. In some patients, conservative treatment is effective, but in others, the broken spinal membrane cannot be repaired on its own through conservative treatment, and the symptoms cannot be relieved, or even prolonged for several years, and many symptoms such as tinnitus, diplopia and depression, and even serious comorbidities such as subdural hemorrhage, hematoma and brain herniation can seriously affect normal life and work, so active intervention to repair the broken spinal membrane through surgery will help patients recover. Intracranial low-pressure epidural interventions are done in the operating room under sterile conditions, and the broken spinal membrane is repaired by injecting autologous venous blood or bioprotein glue or a mixture of both into the epidural cavity of the broken segment under precise pressure regulation through X-ray or ultrasound guidance, resulting in rapid recovery and return to normal life and work for the majority of patients with very satisfactory results. Through years of experience and cooperation and communication with foreign advanced treatment teams, the current low cranial pressure intervention team has only a low incidence of complications such as neurological damage; due to the characteristics of the disease itself, there is a certain recurrence rate and reoccurrence after spontaneous intracranial low pressure intervention, but through early and timely interventions However, satisfactory results can still be obtained through early and timely intervention.