Glutathione is a sensitive indicator of liver function, reflecting the presence or absence of liver cell damage and the degree of liver damage, the normal value of glutathione is 0-40 U/L. Whether glutathione 100 U/L is serious or not depends on the causes of elevated glutathione. First of all, it is necessary to clarify whether the patient is fasting when doing the test, whether he/she is drinking alcohol or exercising strenuously, and then consider pathological factors after excluding physiological factors, common pathological factors include drug-related liver damage, alcoholic liver disease, viral hepatitis, etc. Second, it should be combined with other examinations, including the patient’s primary disease, liver reserve function, and liver imaging findings to make a comprehensive judgment. If the patient has hepatitis, cirrhosis, and elevated glutathione transaminase but normal bilirubin, glutathione transaminase quickly returns to normal after liver-protective treatment and is generally not serious. If the patient has liver failure or decompensation, with elevated glutamic oxalacetic transaminase and elevated bilirubin, the patient has severe cirrhosis, and imaging suggests ascites, the condition is more serious. Elevated glutamic transaminase caused by simple surgical hepatobiliary stones is not serious if the glutamic transaminase drops to normal after the biliary obstruction is removed and the stones are removed. If the patient has liver atrophy, cirrhosis and poor surgical results, and the glutamic transaminase cannot be reduced to normal, then the condition is more serious. Patients are usually advised to avoid alcohol in daily life, avoid fatty and indigestible foods, eat more light foods such as celery and spinach, and pay attention to regular work and rest.