High transaminase of 300U/L cannot indicate early stage of liver cancer. Elevated transaminases mostly indicate abnormal liver function, but it does not mean early stage of liver cancer. The diagnosis of liver cancer needs to be combined with clinical symptoms, imaging examination and laboratory examination. First of all, because transaminases mainly exist in human liver cells, elevated transaminases may be caused by staying up late, alcoholism, liver disease, infection and drug damage, such as fatty liver, viral hepatitis, cirrhosis, cholecystitis or taking lipid-lowering and anti-tuberculosis drugs. Therefore, don’t worry too much when transaminases are elevated, it is not a criterion to diagnose liver cancer. For transaminase abnormalities caused by bad living habits, it will be gradually relieved by adjusting work and rest, less staying up late, light and easy to digest diet, and moderate outdoor exercise daily; for transaminase elevation caused by drugs, hepatitis or other diseases, it can be treated with anti-inflammatory, antiviral and liver-protective treatment under the guidance of doctors, and the symptoms will also be gradually relieved. Secondly, in early stage of liver cancer, transaminases may be at normal level, i.e. less than 40U/L. Only in middle and advanced stage of liver cancer, transaminases may be in elevated state, for example, the value of transaminases in middle stage of liver cancer may be 2-5 times higher, and even higher in advanced stage. Clinically, the diagnosis of hepatocellular carcinoma can be confirmed by detecting methemoglobin, detecting the levels of various enzymes in serum, improving imaging examinations such as ultrasound, CT and MRI, and then combining with histopathological examination. Patients with early stage of hepatocellular carcinoma may have manifestations such as pain in the right upper abdomen, abdominal distension, loss of appetite, general weakness, yellow skin staining and diarrhea. Therefore, if patients are found to have transaminases as high as 300 U/L after examination, they can visit a specialist to rule out hepatocellular carcinoma in combination with whether they have any uncomfortable symptoms.