Although there are various factors that influence the onset of menopausal syndrome, each of which causes different symptoms and severity in different individuals, the most fundamental cause of the changes is the lack of hormones produced by the ovaries, especially estrogen. There is no other treatment that can completely replace estrogen to control the various changes of menopause, because estrogen replacement therapy can solve many problems at the same time: 1. Estrogen can prevent or reduce the discomfort caused by vaginal and vulvar atrophy, prevent and relieve urinary tract menopause symptoms, maintain the uterus and vaginal support tissues in a more normal tension, thus avoiding uterine, vaginal wall, urethral prolapse It also prevents the appearance or aggravation of urinary incontinence, difficulty in sexual life, vulvar dryness, itching and pain, and greatly improves the quality of daily life of menopausal women. 2. Estrogen is very effective in controlling hot flashes and sweating symptoms. The symptoms of dizziness, headache and palpitations are also reduced or disappeared as a result. Some symptoms such as anxiety, depression, agitation and paranoia may also improve. After taking the drug for a period of time, many people’s whole mental outlook changes, like a new person, they feel relaxed and energetic, no longer tired and bored, pessimistic and disappointed, the whole family atmosphere also becomes warm and harmonious, and the interaction with people also returns to normal harmony. 3, estrogen also has a good effect on the skin because it stimulates collagen synthesis in the skin. Skin that lacks collagen will become thin and wrinkled. Taking estrogen can maintain the skin at a level close to that of pre-menopause and slow down the aging of the skin. 4.Taking estrogen can reduce the degree of breast atrophy and sagging. 5. Estrogen replacement therapy can prevent the loss of bone mass and thus reduce the risk of fracture. The effect of estrogen on the heart is double-edged. Estrogen can increase HDL cholesterol and decrease LDL cholesterol in the blood and significantly reduce the incidence of coronary heart disease in women and prolong life expectancy. However, for women with existing cardiovascular pathology, estrogen may affect blood clotting function and lead to earlier onset of disease. Therefore, it is recommended to start supplementing early, preferably within 5 years of menopause.