Precocious puberty is an abnormality of pubertal development, manifested by the early appearance of pubertal features. The incidence of this disease has increased significantly in recent years and has become one of the most common pediatric endocrine diseases, while precocious puberty occurs four to five times more in girls than in boys. The danger of this disease to the affected children is mainly manifested in two aspects: firstly, due to the early puberty, the sexual characteristics appear early, and in girls, breast development and even menstruation often appear prematurely, but life is not yet self-care, and the intelligence and sexual psychology of the affected children are not yet mature, so they are prone to social problems, thus causing mental and care burdens to parents. On the other hand, the early appearance of sexual characteristics is often accompanied by accelerated skeletal growth, so although the affected children are temporarily taller than children of the same age, their epiphyses fuse earlier, so they tend to be shorter than normal in adulthood. Delayed puberty is another abnormality of adolescent development, which is characterized by a significant delay in the onset of puberty compared to children of the same age. However, in children with congenital or acquired organic diseases of the hypothalamus-pituitary gland or gonads, most of them have hypogonadism, resulting in low gonadal function. However, in children with congenital or acquired organic disorders of the hypothalamus and pituitary gland, most of them have hypogonadism, resulting in poorly developed reproductive organs and sexual characteristics, and are often unable to have children.