Estradiol is not usually used alone to determine precocious puberty and needs to be combined with other test results.
Estradiol changes periodically with menstruation, and the normal value of estradiol varies greatly at different times. Therefore, estradiol is not usually used as the basis for determining precocious puberty.
For common sex hormone tests, the main test for girls is luteinizing hormone (LH), which is usually between 3.0 and 5.0 IU/L. If it is more than 5.0 IU/L, it is certain that the gonadal axis is activated, and there is no need for gonadotropin-releasing hormone stimulation test to confirm the diagnosis. In boys, the main focus is on testosterone (T), with values above normal indicating possible precocious puberty.
However, the 6 sex hormones in children are only a basic screening test, and the gonadotropin-releasing hormone test is the gold standard for diagnosis. A combination of imaging tests is also needed.