Children with precocious puberty precocious puberty is divided into central precocious puberty (true precocious puberty), peripheral precocious puberty (pseudo-precocious puberty), generally idiopathic central precocious puberty, the doctor judged that affects the height of the development of gonadotropin-releasing hormone analogues only need to be injected. Other causes of precocious puberty need to be treated according to the cause of the disease.
There are many causes of precocious puberty, if it is caused by tumor, trauma or other diseases, usually do not need to take injections, first for the cause of the treatment can be. In idiopathic central precocious puberty, there is gonadotropin-releasing hormone dependence, so gonadotropin-releasing hormone analogs need to be injected.
The main danger of gonadotropins is premature epiphyseal closure, which affects the final height of the child. Therefore, not all cases of idiopathic central precocious puberty require treatment. In general, doctors will determine the need for medication based on bone age and predicted adult height under the following conditions:
1. Bone age is 2 or more years older than age, but bone age is ≤11.5 years.
2. Predicted adult height: girls <150cm, or height SD <-2SD judged by bone age (judged by normal population reference value or genetic target height).
3. Rapid developmental progression, bone age growth/age growth >1.
If precocious puberty progresses slowly (bone age progression does not exceed age progression) and does not have a significant effect on adult height, or if bone age is advanced but height growth is rapid, adult height is not predicted to be affected. Treatment with injections may not be required for the time being.