Precocious puberty in girls is categorized into central precocious puberty (true precocious puberty) and peripheral precocious puberty (pseudo precocious puberty), which can be treated with medication and surgery.
Central precocious puberty (true precocious puberty) is generally due to premature activation of the hypothalamic-pituitary-gonadal axis. It may be idiopathic (which is common in girls), or it may be caused by factors such as hypothalamic tumors, infection, or trauma.
Peripheral precocious puberty (pseudoprecocious puberty) is not related to the hypothalamic-pituitary-gonadal axis. It may be caused by gonadal tumors, or by adrenal gland disease or external ingestion of food or drugs.
Treatment needs to identify the cause of the disease and make a clear diagnosis before targeting treatment.
1. Idiopathic central precocious puberty (true precocious puberty): due to gonadotropin-releasing hormone dependence, gonadotropin-releasing hormone analogs are generally taken to regulate the treatment. Such as treprostinil, leuprolide and so on.
2. Tumor: surgical resection of tumor or radiotherapy treatment is needed according to the situation.
3. Peripheral precocious puberty (pseudo-precocious puberty) caused by other diseases: girls with precocious puberty caused by hypothyroidism can be given thyroid preparations to correct the function; girls with precocious puberty caused by adrenocortical hyperplasia can be treated with adrenocorticotropic hormone.
4. Sex hormone intake from the outside: Check for sex hormone-containing food and drugs in the living environment and stop intake.
The causes of precocious puberty in girls are complex, it is recommended to consult a doctor as soon as possible, according to the causes to take reliable scientific treatment, the above medication in accordance with the doctor’s instructions.