Donor insemination is a technique to insert sperm from a sperm donor into the female reproductive tract at the right time to achieve conception through non-coital methods. It is suitable for azoospermia caused by various reasons, especially non-obstructive azoospermia, testicular puncture without sperm, or the male partner has hereditary diseases such as mental illness, epilepsy, severe mental retardation, or the couple has severe maternal-infant blood group incompatibility due to special blood type that has failed to be treated. Because of the moral, legal and ethical issues involved, artificial insemination by sperm donation requires strict follow-up and management, and must be strictly enforced in accordance with the relevant national regulations. The waiting time for artificial insemination by sperm donor is about 1 month at our center. Both parties should be seen together at the time of consultation and bring previous examination reports.