There are many arguments about the origin and spread of syphilis (syphilis), according to Western scholars, there was no syphilis in Europe before the 15th century. 1492 Columbus made his first voyage to America, some sailors had sexual relations with American women, and when the sailors returned to Europe, they spread the disease to Italy and Spain. 1494 King Charles VIII of France collected more than 300,000 soldiers from various countries, and the expedition to Italy, syphilis was spreading in the army camps when the siege of Naples. The expedition to Italy, syphilis was spreading within Italy, when the siege of Napoli, a syphilis pandemic occurred in the military camps. 1495 these soldiers with syphilis returned home, causing a syphilis epidemic in Europe. Some believe that the Portuguese fleet brought syphilis to India in 1488. Some scholars also believe that Columbus’ fleet rounded the Cape of Good Hope and reached India in 1498. The arrival of the syphilis-infected crew brought syphilis to India as well. Through commercial exchanges, syphilis also entered China. In 1505, syphilis cases were first discovered and recorded in Guangdong Province, and since then, syphilis has spread widely in China from the coast to the interior, with a high incidence rate, ranking first among venereal diseases. After liberation, as the Party and government effectively banned brothels, prohibited prostitution, and conducted extensive census and treatment of STDs, syphilis was basically eliminated in 1959 after ten years of efforts, and in 1964, China announced to the world the basic elimination of STDs, a move that shocked the world and stirred the nation. Since the 1970s, with the development of society, venereal diseases have returned from the dead in China, especially syphilis has greatly increased, and the number of cases has risen sharply. The pathogen of syphilis is a spirochete, which can be present in the skin mucous membrane sclerotia, rash, and body fluids of syphilis patients. When having intercourse with a healthy person, the spirochete enters the damaged skin mucosa of the healthy body with the secretions (even if the damage is very small and invisible to the naked eye), and the contact person is infected. Very rarely, the infection can be transmitted through blood transfusion or contact with objects contaminated with syphilis spirochetes. Syphilis can be passed from mother to fetus. The medical term Tre-ponema palidum was discovered and reported by French scientists Schaudinn and Hoffmanu in 1905.