Each person has a different tolerance, perception, and sensitivity to medications. Generally, it takes about 10 days or 2 weeks after the use of antidepressants for them to take effect. This is because it takes a process for the drug and the receptor to bind, and it needs to be regulated by the brain and the physiological neural network to work. Unlike a cold or fever, which immediately goes down when you take antipyretic drugs, depression has a process after taking medication. In some cases of refractory depression, it may take 4-6 weeks to take effect, so I think the main thing in the treatment of depression is standardized treatment. That is, we should take the medication systematically and not to take 1-2 days and then not to eat. Because the effect of intermittent medication is very bad, must be standardized. Secondly, in the process of medication to adjust the amount of drugs, to achieve the effective dose. That is, in the process of medication should be adjusted according to the patient’s situation, not that a medication will be effective immediately. So whether it is a patient with depression, or family members, to have patience to treat, to regulate the treatment, the treatment effect will be good.