Some people will be red in the face after drinking some wine, and people will think he is a good drinker, is that really true? After we drink, alcohol enters the blood through the digestive tract and is mainly metabolized through the liver, except for a small portion that is excreted through breathing and urine. Catalyzed by the first enzyme, ethanol dehydrogenase, it is metabolized from ethanol to acetaldehyde, and under the action of the second enzyme, acetaldehyde dehydrogenase 2 (ALDH2), it is changed from acetaldehyde to acetic acid, and finally acetic acid is oxidized to carbon dioxide and water and eliminated from the body. It can be simply understood as: ethanol → acetaldehyde → acetic acid → carbon dioxide + water If the first enzyme is normal, ethanol → acetaldehyde is converted smoothly, while the second enzyme (ALDH2 gene defective) is not normal, acetaldehyde can not be converted smoothly into acetic acid, it will make acetaldehyde accumulate in the body, the capillaries on the face will be dilated, and eventually lead to blushing. So, people who drink and blush are actually not drinking. Compared to Europeans and Americans, Asians are more likely to blush when they drink, and are known as Asian Red Face (AaianFlush). If both enzymes are lacking, the alcohol can only be broken down slowly by the liver. Such people may look white because of the lack of the former red warning effect, giving the impression that they “seem to be very good at drinking”, but in fact, they drink more than the red-faced people also hurt the liver. If both enzyme activities are high, it is really good drinking (meet such people is also drunk). Of course, it does not mean that people who drink without blushing can drink without fear. Because, no matter how good you are at drinking, the more you drink, the greater the impact on your liver, cardiovascular and so on. Excessive drinking is one of the causative factors of liver disease (fatty liver, perivascular fibrosis, alcoholic hepatitis, cirrhosis), and also increases the risk of many cancers such as hypertension, obesity, stroke, and breast cancer, as well as leading to accidents (such as DUI), domestic violence, etc. Therefore, if you must drink, you need to limit it; if you are not currently drinking, it is not recommended to start going.