In the current context of rapid social development, the chances of depression are getting higher and higher. Probably inadvertently, we hear about suffering from depression from TV media, friends around us, etc., but most of us probably do not know about the causes of depression. Depression is a psycho-psychological disorder and a state of mind in which a person suffering from depression experiences a prolonged state of low mood, which can spread to all your normal life. Depression is also a disease caused by a combination of social-psychological-physiological effects. Next, we will discuss the mechanisms of depression pathogenesis from these three aspects: Physiological basis: The pathogenesis of depression has first a certain biological basis, that is, a genetic basis. It is possible that these populations originally carry some susceptibility genes, although it is not clear what kind of genes are clearly identified, but the available studies suggest that such This is also the theoretical basis for our treatment with antidepressants, which are designed to improve depression by adjusting the content of these neurotransmitters in the brain. Psychological basis: The reason why depression is also a psychological disease is that psychological factors also have a pivotal influence in the development of depression. In general, many depressed patients have a certain personality base before the onset of depression, and their behavior patterns and ways of coping with crises are definitely biased, such as being more likely to adopt a retreating or negative attitude in the face of frustration; internal attribution, easily taking the process on themselves, regardless of the event; lack of self-identity, overestimating themselves, and not accepting their imperfect selves, etc. . These are the areas that are treated through psychological interventions. Social factors: Many patients will have a certain social stressful event before they become depressed, the impact of this event on the patient does not depend on the actual size of the event, but more on the assessment of the severity of the event from the patient’s point of view, for example: a girl fell out of love, which may seem the most common thing to people around her, but if the girl herself has a high self-esteem of this event, it may be a traumatic experience for her. Therefore, this aspect is also related to psychological cognitive processes and needs to be complemented by psychological interventions to help cope with these stressful events. Although all three aspects play a role in the development of depression, there is a great deal of individual variation, and some may be more due to biological factors, which we tend to call “endogenous depression. Some may be more due to stressful life events, which we tend to refer to as “exogenous depression,” and they may have abnormal treatment choices and priorities, making treatment for depression comprehensive and variable.