The main lies in follow-up monitoring. Through strict and standardized long-term follow-up, we can avoid blind medication for patients who do not need treatment, and not to miss patients who need treatment. 1, follow-up interval: for those with normal ALT and negative HBV DNA, it is recommended to follow up once every 6-12 months. For those with normal ALT but positive HBV DNA, it is recommended to test once every 3-6 months. 2.Follow-up examination items: should include liver function, HBV DNA, AFP, ultrasound. In case of chronic HBV carriers with positive HBV DNA, liver aspiration should be performed. Especially for those who are over 40 years old, have a family history of hepatitis B, transaminases at the high limit of normal, and abdominal ultrasound suggesting diffuse liver lesions or enlarged spleen, it is best to mobilize them for liver puncture to further clarify the liver lesions and treat accordingly as appropriate. Li Jie, Department of Infectious Diseases, Second Hospital of Wenzhou Medical University 3, carriers who need antiviral treatment: carriers with liver puncture results such as inflammatory grade G≥2,S≥, or with significant fibrosis, need to be treated with antiviral therapy; once the ALT is found to be elevated more than 2 times the upper limit of normal during follow-up, and excluding alcohol, drugs, and at the same time HBV DNA positive, need to be treated with antiviral therapy.