Premature ovarian failure usually occurs in women with regular menstruation before the age of 40, but not all patients with premature ovarian failure will necessarily experience the 7 symptoms. Typical clinical manifestations include menstrual disorders, such as oligomenorrhea or amenorrhea, infertility, low estrogen symptoms, such as decreased libido, and symptoms of atrophic urethritis, such as frequent and painful urination, as well as manifestations of certain autoimmune diseases, such as rheumatoid arthritis and vitiligo. In addition, premature ovarian failure may be accompanied by complications such as osteoporosis or heart disease: 1. menstrual disorders: if women before the age of 40 have scanty menstruation, menstrual disorders or reduced menstrual flow or even gradual amenorrhea, sudden amenorrhea in those with regular menstruation, no menstrual flow after discontinuation of birth control pills or termination of pregnancy, etc., it is likely to indicate premature ovarian failure; 2. infertility: patients with premature ovarian failure, according to the time of onset 3. Low estrogen symptoms: Patients with premature ovarian failure often have hot flashes and sweating, panic attacks and insomnia, as well as symptoms of reduced estrogen such as vaginal dryness, breast atrophy and decreased libido, and some patients may even experience emotional or cognitive changes; 4. symptoms of atrophic urethritis, as well as vaginal dryness, painful intercourse, or vaginitis; 5. autoimmune diseases: some autoimmune diseases may also appear after premature ovarian failure, such as primary chronic hyperalgesia, thyroid disease, rheumatoid arthritis, etc.; 6. other complications: reduced estrogen levels may also cause decreased bone density, leading to osteoporosis, or cause hyper cholesterolemia, thus increasing the risk of atherosclerosis and other cardiovascular and cerebrovascular diseases.