Vaccines to prevent cervical cancer are useful because there is a clear correlation between the occurrence of cervical cancer and the human papilloma virus, which is responsible for more than 99.4% of cervical cancers. The HPV vaccine is the first and only vaccine against malignant tumors in the world, and it has been confirmed to be effective. . Other tumors are also being researched in this area, but there is no established vaccine available to the market. So cervical cancer prevention with HPV vaccine has different stages of development, from the earliest bivalent cervical vaccine to the intermediate quadrivalent to the current nine-valent. The HPV vaccine has adapted age stages, including bivalent, quadrivalent and nine-valent, and the overall vaccine use is about 16-45 years old, and it is best to use it before sexual intercourse occurs, which can achieve the effect of reducing the occurrence of cervical cancer and the chance of precancerous lesions by more than 90%.