Chronic liver disease has a remarkable four “sexes” – curable, recurrent, difficult to treat, and progressive. With the progress of science and technology, there are corresponding treatment drugs and treatment plans for various chronic liver diseases, and most of them can be effectively controlled under the standard treatment of specialist doctors. However, chronic liver diseases have a common feature, that is, they are prone to recurrence, including hepatitis B, fatty liver, cirrhosis, autoimmune liver disease and so on. All types of chronic liver diseases are relatively difficult to treat, such as fatty liver, most of these patients have bad habits, work habits, diet, etc., lack of exercise, and these bad habits are difficult to change, which determines the difficulty of treating fatty liver; and then chronic hepatitis B, although there are interferon and nucleoside (acid) analog drugs to choose from, but it is clinically difficult to cure, and many patients need long-term treatment to control the disease. Chronic liver disease is relatively difficult to cure, and if the disease fluctuates repeatedly, it will continue to progress. The above four “natures” demonstrate the importance of standardized treatment, but also highlight the need for regular review and follow-up. In clinical practice, we encounter a group of patients – “medication dispensers” – who dispense medication for a long time and neglect regular review and follow-up. They think that they have already taken medication and have been examined several times, so they think that they will be fine as long as they take medication and there is no need for regular review and follow-up visits, which can save both money and time. When I meet such patients, I mostly tell them to review the indicators at the right time, and then let the doctor look at them to evaluate the effect of the treatment after taking the medication, whether the medication needs to be changed or increased, whether the disease is effectively controlled, and what to do next. For example, chronic hepatitis B antiviral treatment, regular review and follow-up can effectively avoid the following problems: 1, the treatment is not effective, after taking drugs did not effectively control the virus replication, regular review, to understand the disease, to facilitate changes in the treatment plan; 2, the disease relapse, after treatment, the virus replication turned negative, after a period of time the virus replication is positive, may be drug resistance, may be the drug efficacy is not good; 3, adverse drug reactions, such as thyroiditis, leukocytes. For example, thyroiditis, lowered white blood cells or platelets, elevated creatine kinase, depression, etc.; 4, complications, whether cirrhotic patients are complicated by esophagogastric fundic varices, ascites, hepatic encephalopathy, and whether they progress to hepatocellular carcinoma. If regular review and follow up can be done, early detection and early treatment can be achieved to avoid adverse consequences. Therefore, taking medication is only the beginning of treatment, and achieving the expected response target is the key. It is important not to neglect regular review and follow-up, so as to be aware of the situation and to adapt to it.