There is no effective vaccine to prevent hepatitis C. Therefore, the first step in preventing the spread of hepatitis C virus is to understand the following: 1. Safe blood use: Strictly implement the Blood Donation Law of the People’s Republic of China and promote blood donation without compensation. Strictly screen blood donors by testing serum anti-HCV and alanine aminotransferase. Detection methods for HCV antigens should be developed to improve the detection rate of those infected during the window period. 2. Prevention of transdermal and mucosal route transmission: Promote safe injection. Medical instruments such as dental instruments and endoscopes should be strictly disinfected. Medical personnel should wear gloves when touching patients’ blood and body fluids. Provide psychological counseling and safety education to intravenous drug users to persuade them to quit. Do not share razors and dental instruments, etc. Haircutting utensils, piercing and tattooing utensils should be strictly disinfected. 3. Prevention of sexual transmission: People with a history of sexual promiscuity should be examined regularly and management should be strengthened. It is recommended that HCV-infected persons use condoms during sexual intercourse. Proper sex education should be provided to adolescents. 4. Prevention of mother-to-child transmission: For pregnant women with positive HCV RNA, amniocentesis should be avoided, the delivery time should be shortened as much as possible, the integrity of the placenta should be ensured, and the chance of exposing the newborn to maternal blood should be reduced.