I. Artificial insemination by husband
(A) Indications.
1. Male factors: abnormal semen liquefaction, retrograde ejaculation, sexual dysfunction, genital tract abnormality, etc. ICI treatment can be considered if the semen routine parameters are normal.
2, male oligospermia and weak spermatozoa can be treated with IUI after sperm preparation, but the number of forward-moving sperm after preparation should not be less than 5 million (too small a number of forward-moving sperm will decrease the clinical pregnancy rate).
3. female factors: the female partner has at least one completely patent fallopian tube and the iodine oil imaging of the fallopian tube confirms that there are no pelvic adhesions affecting the egg collection function of the fallopian tube, but there are cervical factors such as infertility; or reproductive tract malformations and psychological factors leading to sexual intercourse disorders; or ovulation disorders after ineffective ovulation promotion treatment; or endometriosis.
4. immunological factors: semen anti-sperm antibody test in which at least 50% or more active sperm encapsulation is found in one semen sample and confirmed after assessment of the biological importance of the antibody by sperm-cervical mucus contact test, in vivo post-coital test, in vitro sperm-cervical mucus contact test, etc.
5. unexplained infertility.
6.Compliance with family planning policy.
(II) Contraindications.
1, one of the male or female suffers from acute genitourinary infection or sexually transmitted diseases.
2, one of the parties suffers from serious genetic, somatic diseases or psychosomatic disorders
3, one party is exposed to teratogenic amount of radiation, toxins, drugs and in the period of action.
4, one party has drug addiction and other bad habits.
B. Artificial insemination by sperm donation
(A) Indications
1, testicular azoospermia, obstructive azoospermia, severe oligospermia, weak spermia and deformed spermatozoa.
2, failure of vasectomy recanalization.
3, ejaculation disorders.
4, serious genetic disorders in the male partner and/or family that are unsuitable for fertility.
5, the mother and child blood type incompatibility can not get a surviving newborn.
Note: Indications 1, 2 and 3, the ICSI technology needs to be explained to the patient, the patient refuses to sign an informed consent form at the same time before the implementation of sperm donation.
(ii) Contraindications
1, the female partner suffers from acute infection of the genitourinary system or sexually transmitted diseases.
2, the female partner suffers from serious genetic, somatic diseases or psychosomatic disorders
3, the female party is exposed to teratogenic amount of radiation, toxins, drugs and in the period of action.
4, the female party has drug addiction and other bad habits.
III. Conventional in vitro fertilization technique
Indications
1.Infertility caused by blockage or dysfunction of fallopian tubes resulting in obstruction of sperm-egg transport.
2, endometriosis.
3.Mild oligospermia and weak spermatozoa in men.
4. infertility of unknown origin.
5. infertility due to ovulatory dysfunction
6, infertility caused by other reasons: such as immune infertility, reduced fertility due to age factors, and fertility reserve in cancer patients.
IV. Intracytoplasmic sperm injection (ICSI) technique
(A) Indications
1.Severe oligospermia, weakness and teratogenesis.
2, irreversible obstructive azoospermia. testicular or epididymal spermatozoa.
3, spermatogenic dysfunction (excluding those due to genetic disease defects).
4, immune infertility.
5, history of unexplained conventional fertilization failure. For previous IVF with conventional fertilization failure or fertilization rate less than 20%, when the patient undergoes IVF treatment again, the ICSI technique is recommended for this cycle.
6, sperm without acrosome or abnormal acrosome function.
7, the need to use PCR technology to diagnose the PGD cycle
(B) ICSI contraindications
1, one of the men and women suffering from serious mental disorders, acute genitourinary infections or sexually transmitted diseases.
2, suffering from genetic diseases that are not suitable for childbirth as stipulated in the Maternal and Infant Health Care Law and are currently not available for pre-implantation genetic diagnosis
3.One party has bad habits such as drug addiction
4, one of the parties is exposed to teratogenic amounts of radiation, toxins, drugs and is in the period of action
5.The female party’s uterus does not have the function of pregnancy or serious physical disease cannot bear pregnancy.
Note: Modified from “Clinical Diagnostic and Treatment Routines in Reproductive Medicine”, the copyright belongs to the book, please cite the source if quoted.