What are the manifestations of multiple myeloma? Multiple myeloma is a malignant plasma cell disease with insidious onset that most often occurs in people over the age of 50. Bone pain is one of the most common symptoms of multiple myeloma, which is easily treated as osteoporosis and rheumatoid diseases, and the initial misdiagnosis rate of the disease is over 50%. This is because myeloma cells secrete osteoclast-activating factors that activate osteoclasts, causing bone lysis and destruction and resulting in bone pain. Bone pain occurs mostly in the lumbosacral region, followed by the thoracic ribs and long bones of the extremities. Due to the destruction of bone by tumor cells, it will cause widespread osteoporosis throughout the body and easily develop multiple fractures throughout the body. In addition, malignant plasma cells proliferate and secrete large amounts of monoclonal immunoglobulins, which can also cause anemia, renal impairment, recurrent infections, and hyperviscosity syndrome, among other manifestations. Multiple myeloma is mostly seen in middle-aged and elderly people, but in recent years, there is a trend of youthfulness, and some patients are even younger than 30 years old. Therefore, if middle-aged or elderly people have unexplained back pain, bone pain, osteoporosis, especially age-appropriate osteoporosis, or symptoms such as anemia, proteinuria, recurrent lung infections, etc., they should pay great attention and visit the hematology department to clarify whether they have multiple myeloma. Is there no cure for this disease? It is not true. With active and standardized treatment, bone pain can be relieved and the 5-year survival rate can reach 40%. In recent years, the use of new targeted drugs, including bortezomib, thalidomide and ranadomide, has significantly improved the quality of life and survival of patients. The combined application of hematopoietic stem cell transplantation in young patients can effectively improve survival. The current new view on the treatment of this disease is to make multiple myeloma a chronic disease without a cure, so that the tumor cells become hibernating bears that do not proliferate and prolong the survival of patients as much as possible; emphasis is placed on trying to obtain a high-quality complete remission with each treatment, and the highest treatment goal to be pursued in the future is a clinical cure (complete remission >10 years). Patients are advised not to seek medical help in an emergency, but to seek regular treatment; do not take supplements indiscriminately during treatment, and a diet as usual is sufficient. Be psychologically prepared for long-term treatment of the disease, and do not believe in the biased prescriptions.