Leukoplakia is characterized by recurrent oral and genital ulcers, ophthalmia and skin damage. This disease belongs to the category of fox disease in Chinese medicine. The etiology of this disease is considered by many physicians to be related to poisonous evil. For example, Chao Yuanfang’s “Treatise on the Origin of Diseases” points out that this disease “is caused by dampness and toxicity”, Wu Qian’s “Jinjian of Medicine” believes that “it is caused by the residual toxicity of typhoid fever and the harm of lust”, and the recent Yue Meizhong says: “fox confusion disease is a warm and hot disease treated The transformation of the disease is a serious illness in which the evil poison is not released and finds its own way out.” This article intends to explore the etiology of the disease from the perspective of poisonous evil. The spleen is responsible for clearing and the stomach is responsible for lowering turbidity. Normal function of the spleen and stomach, the transformation of the essence, gas, blood, fluid enough, the organs, meridians, limbs and bones and fur can be fully nourished, normal physiological function. If you are not able to eat and drink, or if you are a fan of thick, spicy, fatty, alcoholic and greasy products, you will not only be unable to transform the qi and blood, but also stagnate the spleen and hinder the stomach, affecting the function of the spleen and stomach. The “Su Wen – Theory of Paralysis” says: “If the diet is doubled, the intestines and stomach are injured.” When the spleen and stomach are damaged, the clear yang does not rise and the cloudy yin does not descend, so the water and grain essence cannot be dispersed, blocking the middle jiao and creating dampness and turbidity. This provides the conditions for the generation of internal toxicity and becomes the source of toxicity. This disease is mostly seen in young and middle-aged people. In the case of men, it is between the ages of “2-8” and “4-8”. The “Su Wen – Shang Gu Tian Zhen Lun” said: “Husband, two eight, the kidney is full of energy, the sky is full of sebum, four eight, tendons and bones, muscles full of strong”, when the kidney is full of energy, life in the prime of life, the organism is hyperactive Yang Qi, “the surplus of Qi is fire”. In addition, when the man’s career is thriving and developed, such as the day, socializing frequently, alcoholic wine, nourishing, spicy, fatty and sweet products are not away from the mouth, the sound of goblets and chips incessantly. The spleen and stomach are repeatedly damaged, the retention of dampness and turbidity, from the Yang into heat, brewing poisonous evil. The woman “two seven and the day sebum to, any vein through, Tai Chong vein Sheng, menstruation to the time, so there are children, four seven, tendons and bones firm, hair long pole”, is in the period of pregnancy and birth breast, all with blood, easy to deplete the qi and blood. The “Spiritual Pivot・Wu Yin Wu Wei” said: “The birth of women, surplus in gas, deficient in blood, with a view to the number of blood off.” The surplus of qi is fire, insufficient yin and blood, easy to produce internal heat, dampness from which heat, resulting in the internal growth of poisonous evil. 2, emotional and mental disorders, heat and toxicity within the birth Emotional and mental is the body’s different responses to objective things and phenomena, the human body’s emotional and mental activities are closely related to the internal organs and blood. Su Wen – Yin and Yang should be like the great theory of cloud: “people have five organs into five qi, to produce happiness, anger, sadness and fear”, it can be seen that the material basis of emotional activity is the five organs of the essence of blood. Only sudden, strong or long-term persistent emotional stimulation exceeds the range of regulation of the body’s own physiological activities, causing disorders in the function of the internal organs of Qi and blood, will lead to the occurrence of disease. In modern society, the pace of life is accelerating, and the pressure from family, life and society is increasing. All will make people appear the seven emotions too extreme, and hurt the internal organs of Qi and blood, resulting in qi depression, depression for a long time into heat, that is, “five will be too extreme, all from the fire”, “gas is surplus is fire” said, which leads to internal heat poison, such as “clinical guide to medical cases” Hua Xiuyun said: “depression is qi stagnation, qi stagnation, qi is fire: “Depression is qi stagnation, qi stagnation for a long time will turn into heat. Second, the development of poison 1, the internal organs are out of order, poisonous evil stagnation contained “things that can harm people are called poison”, the ancient text poisoning can refer to the cause of disease, disease, drug bias, poison, etc.. And here refers to the accumulation of endogenous evil (dampness, heat evil) fierce, brewing stubborn evil formed on the body with strong damaging effect of disease-causing substances. The former diet and dampness and heat toxicity, emotional and mental disorders and heat toxicity, if the internal organs function in harmony, or can be poisoned to go to the safe, so that the body in a relatively non-toxic state of equilibrium; if the body Yin and Yang imbalance, or the five will be too extreme, the seven emotions within the heart, liver, spleen and kidney and other internal organs malfunction, can not clear the source of toxicity, detoxification, so that the poisonous evil stagnation, waiting for the opportunity to develop. It can be seen that the imbalance of the internal organs, poisonous evil contained within the pathogenesis of the disease is the basis. 2, the external evil induced, the poisonous evil attack note poisonous evil within the ambush, if not touched, only dark depletion of qi and blood, the harm is not obvious, or as normal. If the external dampness and heat poisonous evil, or because of the internal ambush of poisonous evil and injury to the righteousness, the righteousness is insufficient, the external defense is not solid, more likely to feel the evil. The evil attack, or times eat spicy, fatty, sweet, thick and greasy products, or mismanagement, abuse of warming drugs, or even hormones and other virile things, so that the damp-heat contained in the poisonous evil boiling, no way to vent and find their own way out. Fire inflammation, along the meridians on the throat, mouth and tongue; wetness tends to down, it is injected in the vulva; or injected in the joints, or infiltrate the muscle skin. 3, blood and blood vessels are out of harmony, wet stasis and poison knot veins for the blood of the House, veins is a relatively closed pipeline system. Blood in the veins and tubes run endlessly, flowing throughout the body, around the circumference of the endless, in order to nourish the body inside and outside the upper and lower. Therefore, the normal circulation of blood depends on the integrity and smoothness of the vascular system. The blood gets cold is condensed, get warm is line, fire poison invade blood vessels, light can expand blood vessels to speed up blood flow, and even burn veins, forcing blood delusion, blood overflow outside the veins to form blood stasis. Or damp-heat toxins consume qi and injure yin, blocking the qi flow, making the blood weak, sticky and stagnant. The combination of dampness, heat, stasis and poison makes the poisonous evil more violent and tenacious, attacking the skin, then erythema nodosum; even invade the brain and veins, and the serious disease of partial withering. 4. Poisonous evil for a long time, consume gas and hurt Yin wet sticky, poisonous evil lingering for a long time, is bound to consume blood and fluid. If the body is Yin deficient, or the woman loses blood and essence, or the man is inordinately laboring, the Yin essence is already deficient, plus the poisonous evil attack, so that the Yin essence is deficient, the positive qi is depleted, and the remaining poison is not eliminated, and the disease is lingering and does not heal for years, there may be weakness, the five hearts are hot and bothered, the tongue is red and less mossy, the pulse is thin and other signs of Qi and Yin deficiency. Insufficient positive qi, the external guard is not solid, more likely to feel the external evil, the evil attack, positive qi failed to resist the evil out in time, the evil stays, attracting the remaining evil, the internal and external combination, the evil poison surge; or due to improper diet, eating spicy, fatty and sweet; or sudden emotional and emotional too extreme, and the internal organs function damage is even more, the poisonous evil inside, and the remaining poison accumulation plus, the poisonous evil rekindled, and cause the disease repeated. In short, the etiology of the disease is the dysfunction of the internal organs, poisonous evil (dampness, fire poison), poison and stasis blend, accumulation of fierce, brewing stubborn evil, so that the poisonous evil boiling, through the meridian attack down, resulting in the occurrence of the symptoms. Third, the manifestation of poison 1, the external manifestation of poison 1) ulceration. The disease is mainly manifested by repeated ulceration pain in the mouth, tongue and throat, vulva and red eyes. The poisonous evil lies within, and when the external evil is triggered, it finds its own way out, and the damp-heat and stasis poison attacks and flows. If the disease is attacked along the heart, liver and spleen meridians, the mouth, tongue and throat become ulcerated, swollen and painful, and the eyes become red and photophobic and tearful; if the dampness tends to go down, or is injected along the liver meridians, the vulva becomes ulcerated and the leucorrhoea becomes thick. (2) Invasion of joints and skin. Toxic evil attack, external immersion in the skin, can not be released, stagnant and harmful, visible skin erythema nodosa; injury to the skin of the blood channels, can lead to skin ulceration, erythema lingering; injection in the joints, toxic evil paralysis meridians, the joints swollen and burning; wet evil tends to go down, mostly seen in the lower limbs of the joints and skin damage. (3) Long-term disease attack and internal organs. If the poisonous evil is prolonged, it will attack the lungs, coughing and hemoptysis; if it is trapped in the spleen and stomach, “not wanting to eat and drink, and smelling bad”; if it disturbs the mind, “not wanting to sleep silently, eyes cannot be closed, restlessness in lying down”, or even partial loss of limbs, dizziness and delirium. 2, toxic activity indicators The disease may have elevated peripheral blood leukocytes, increased sedimentation, increased C-reactive protein, increased α2 globulin and γ globulin, increased IgA, IgG, prolonged lysis time of cold globulin. There may be anti-human oral mucosal cell antibodies and circulating complexes in the serum, elevated serum complement and disproportionate lymphocyte subsets, inverted CD4+/CD8+ ratio, and lack of CD45RA+ cells. A series of indicators of the humoral cellular immune system can give a glimpse of the presence and activity of toxic evil. Internal toxicity is an important factor in the pathogenesis of the disease and plays an important role as a link and clue in the whole pathogenesis process. With poisonous evil as the main line, the disease goes through three stages: internal poisonous evil – poisonous evil boiling – positive deficiency and poisonous love. In the initial stage, due to poor diet or emotional disorders, repeatedly leading to internal disorders of the internal organs, internal dampness and heat, dampness and heat for a long time, breeding poisonous evil, poisonous evil contained within, ambush and waiting for development. At this time, because the positive energy is still full, the poisonous evil is still weak, powerless to attack, the patient as normal, or poisonous evil occasionally, a little discomfort, spin back that is healed. Later, because of the old habits as before, the internal organs function disorder is even more, the internal poison accumulates, its potential gradually manifested, the dark depletion of qi and blood, the positive qi gradually loss; if the external evil induced, or the positive qi suddenly reduced, will lead to the poisonous evil boiling, flooding into a disaster; poisonous evil can not vent, find their own way out, along the meridians up attack down injection, and cause the mouth and tongue vulva ulcers, joint pain; poisonous evil injury to the blood vessels, blood stasis, poison and blood stasis intertwined its potential more violent, light erythema nodosum, serious The poison attacks the brain and leads to paralysis and impotence. In the later stage, the positive qi is crippled, unable to dispel the evil, and the poisonous evil also decreases most of it, in the deficiency of positive qi, the poisonous evil stays in the middle, so the disease tends to slow down, recurring attacks, lingering and difficult to cure.