Depression in the gastrointestinal response, depression is a disorder of the heart, plain patients will show low emotions, reduced interest, reduced thinking, little speech and movement, which will affect the patient’s study and work. When suffering from depression, it can lead to abnormal secretion of various hormones in the brain, which can affect the function of the gastrointestinal tract, and because of depression, it can also lead to dysfunction of the nerves in the internal organs, which is often said that the patient may develop gastrointestinal dysfunction. Therefore, clinically, patients may experience abdominal distension, epigastric pain, precordial discomfort, boredom, dyspepsia, intestinal cramps, abdominal pain, constipation, alternating with diarrhea, and other gastrointestinal discomfort symptoms. After these symptoms, the patient may undergo various examinations, including gastroscopy and colonoscopy, abdominal CT, etc., but no obvious organic lesions are found, which is actually a mental aggravation of physical symptoms, which is often referred to as brain-gut axis changes. In addition, since depressed patients also take some depression medications, these medications also have an effect on the gastrointestinal nerves and affect the function of the gastrointestinal tract.