Glioblastoma grows rapidly and has a short course, with 70% to 80% of patients having a disease duration of 3 to 6 months and only 10% having a disease duration of more than 1 year. The longer course of the disease may evolve from astrocytomas of lower malignancy. Individual cases may present with stroke-like onset due to tumor hemorrhage. Due to rapid tumor growth, cerebral edema and extensive intracranial pressure increase symptoms are obvious, almost all patients have headache, vomiting, optic disc edema with headache, mental changes, limb weakness, vomiting, impaired consciousness and speech impairment. The tumor infiltrates and destroys brain tissue, causing a series of focal symptoms. Patients have different degrees of hemiparesis, hemianesthesia aphasia and hemianopsia. Neurological examination may reveal hemiplegia, cerebral nerve damage, hemianesthesia and hemianopsia. The incidence of epilepsy is less common than astrocytoma and oligodendrocytoma, with approximately 33% of patients having seizures. About 20% of patients exhibit psychiatric symptoms such as apathy, dementia, and mental retardation.