High-risk HPV58 positivity refers to human papillomavirus infection, which belongs to the category of viral infections. The common causes of high-risk HPV58 positivity can be seen in close contact transmission and indirect contact transmission.1. Close contact transmission: Sexual transmission is the most common cause of infection, i.e. HPV58 can be transmitted through genital contact when having sex, and the risk of disease increases if there is a sexual disorder and multiple sexual partners. In addition, the route of infection can also be seen through the skin or mucous membrane transmission, that is, if contact with the infected patient’s lesions of the broken mucous membrane, can also cause infection; 2, indirect contact transmission: HPV58 virus can be transmitted through contact with the objects used by the infected people, if the use of the infected people used clothing, tableware, utensils, etc., there may be infection. In addition, people with low immunity, such as those with diabetes, AIDS, malignant tumors, have a higher risk of infection. In addition, HPV58 infection can be transmitted from mother to child. HPV58 infection can cause tissue and organs to break down and bleed, which can lead to condyloma acuminata, common warts, penile cancer, cervical cancer and other diseases. High-risk HPV positivity, in women, generally refers to positive HPV test results typing indications, and high-risk HPV positivity indicates a higher chance of cervical cancer. For males, the test results should be taken from the coronal area of the penis to determine the typing. A positive high-risk HPV test indicates a higher risk of condyloma acuminata and penile cancer, and further examination is needed to confirm the diagnosis and facilitate follow-up treatment.