Normal human bilirubin mainly comes from aging red blood cells in the blood, and the average life span of red blood cells is 120 days. The hemoglobin released from aging red blood cells undergoes a series of metabolism in the body and finally becomes bilirubin, which is divided into unconjugated bilirubin and conjugated bilirubin and is excreted from the stool and urine respectively. Normally, the blood contains only a small amount of bilirubin. So what are the causes and dangers of high total bilirubin? Causes of high total bilirubin 1, physiological causes of neonatal physiological jaundice, is the symptoms of upper body skin yellowing at birth, no other discomfort, after a few weeks will subside on its own, generally has no effect on newborns, long-term alcohol consumption, strenuous exercise, etc. are likely to cause high total bilirubin, physiological causes of high total bilirubin will generally recover on their own after adjustment. 2.Pathological causes Certain cholecystitis, gallbladder polyps, biliary obstruction, cholestasis, viral hepatitis, cirrhosis, liver cancer, acute jaundice, chronic hepatitis, hemolytic jaundice, gallstones, pancreatic head cancer, etc. can cause high total bilirubin. Pathological causes of high total bilirubin should be examined in a timely manner and treated actively. High total bilirubin is damaging to the liver and may cause liver pain in the long term. For high total bilirubin caused by intrahepatic diseases, it should be treated actively to avoid deterioration of liver disease. The danger of high total bilirubin: 1, high total bilirubin, high indirect bilirubin, other normal, indicating that there is a large amount of destruction of red blood cells in the body, hemolytic jaundice occurs, and may be accompanied by blood transfusion, pernicious anemia and other conditions. 2, high total bilirubin, high direct bilirubin, other normal, indicating obstructive jaundice. The bile duct is obstructed and the bile carrying direct bilirubin cannot be drained out of the body. It may be accompanied by pancreatic head cancer, gallstone disease, biliary tract malformation, bile duct cancer and other diseases. 3.High total bilirubin, high indirect bilirubin and high direct bilirubin indicate hepatocellular jaundice, liver cell damage, liver function is reduced liver can not completely convert indirect bilirubin into direct bilirubin, while the intrahepatic bile duct pressure caused excretion obstruction, direct bilirubin also can not be completely drained to the bile duct, and may be accompanied by acute jaundice, chronic active hepatitis, cirrhosis, liver cancer and other diseases The disease may be accompanied by acute jaundice, chronic active hepatitis, cirrhosis, and liver cancer.